منابع مشابه
Measurably evolving pathogens in the genomic era.
Current sequencing technologies have created unprecedented opportunities for studying microbial populations. For pathogens with comparatively low per-site mutation rates, such as DNA viruses and bacteria, whole-genome sequencing can reveal the accumulation of novel genetic variation between population samples taken at different times. The concept of 'measurably evolving populations' and related...
متن کاملModelling the evolution of protein coding sequences sampled from Measurably Evolving Populations.
Models of nucleotide or amino acid sequence evolution that implement homogeneous and stationary Markov processes of substitutions are mathematically convenient but are unlikely to represent the true complexity of evolution. With the large amounts of data that next generation sequencing promises, appropriate models of evolution are important, particularly when data are collected from ancient and...
متن کاملUsing temporally spaced sequences to simultaneously estimate migration rates, mutation rate and population sizes in measurably evolving populations.
We present a Bayesian statistical inference approach for simultaneously estimating mutation rate, population sizes, and migration rates in an island-structured population, using temporal and spatial sequence data. Markov chain Monte Carlo is used to collect samples from the posterior probability distribution. We demonstrate that this chain implementation successfully reaches equilibrium and rec...
متن کاملModelling evolving populations.
A formalism is presented for modelling the evolutionary dynamics of a population of gene sequences. The formalism was originally developed for describing genetic algorithms. In this paper the formalism is elaborated by considering the evolution of an ensemble of populations. This allows the evolution to be modelled more accurately. To illustrate the formalism the problem of a population of gene...
متن کاملEvolving populations with overlapping
In this paper, we extend a previously published model of an evolving nite population of multi-loci organisms, where the dynamics of the evolving system are described by the cumulants of the population eecacy distribution. We consider the case of overlapping generations and compare it to the previously studied case where generations are discrete. In the weak selection limit, we can solve the dyn...
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ژورنال
عنوان ژورنال: Trends in Ecology & Evolution
سال: 2003
ISSN: 0169-5347
DOI: 10.1016/s0169-5347(03)00216-7